Prompt Title: SARS

Yes, the study you mentioned investigates the potential of targeting -1 programmed ribosomal frameshifting (PRF) in coronaviruses as a therapeutic strategy:

Kelly, J. A., Olson, A. N., Neupane, K., Munshi, S., San Emeterio, J., Pollack, L., ... & Woodside, M. T. (2020). Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. bioRxiv. Link: https://www.biorxiv.org/content/10.1101/2020.11.30.404905v1

There have been efforts to target frameshifting pseudoknots in other viruses as well, since inhibiting this mechanism can disrupt viral replication and protein synthesis. Here are a couple of examples:

1. HIV-1: In the case of HIV-1, the frameshift-stimulating pseudoknot is a potential drug target. A study by Dulude et al. (2002) demonstrates that small molecules, like aminoglycoside antibiotics, can bind to the HIV-1 pseudoknot and affect the efficiency of the frameshift, thus offering a potential therapeutic avenue.

Dulude, D., Baril, M., & Brakier-Gingras, L. (2002). Characterization of the frameshift stimulatory signal controlling a programmed -1 ribosomal frameshift in the human immunodeficiency virus type 1. Nucleic Acids Research, 30(23), 5094-5102. Link: https://academic.oup.com/nar/article/30/23/5094/2401131

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